Important Articles

21 Drugs for Cognitive and Negative Symptoms of Schizophrenia in 2024 【Revised 2024.5.20】

Introduction This article summarizes new drugs in development that may help with cognitive dysfunction and negative symp...
Muscarinic Agonists

KarXT has a high long-term efficacy/ Long-term study results/EMERGENT-4

Introduction The results of a long-term study of KarXT were recently published, and I thought the long-term efficacy of ...
Important Articles

List of antipsychotics under development in 2024【Revised 2024.1.26】

Introduction I'll do as much research as I can about the antipsychotics in development in the list below, and I'll write...
Investigational Drugs

Brilaroxazine/High Efficacy & Mild Side Effects

Introduction In October 2023, the results of a Phase 3 study of brilaroxazine were announced. Brilaroxazine is an antips...
Articles for Beginners

Innovative Schizophrenia Drugs【Summary part 2】Ulotaront, etc.

Introduction (This article is a translation of an article for Japanese readers.) In this article, following on from (par...
Ulotaront

【Ulotaront】U.S. Phase 3 Studies Failed. What’s Next? / Clinical Trial Data

Introduction The results of the Phase 3 trials of Ulotaront were released in July 2023. Two Phase 3 trials were both fai...
Articles for Beginners

Innovative Schizophrenia Drugs【Summary part 1】Muscarinic Agonists

Introduction In this article and the next, I will summarize innovative schizophrenia drugs that will be released in the ...
Muscarinic Agonists

EMERGENT-3【KarXT】Efficacy Compared to Current Drugs in Phase3

Introduction Now that the results of KarXT's second Phase 3 trial are in, I have a lot to think about. This trial is cal...
Ulotaront

A lot of benefits of taking【Ulotaront】: A new antipsychotic drug

Introduction Ulotaront acts as a TAAR1 agonist and a 5HT1A receptor agonist. I found a review article that describes the...
Ulotaront

【Ulotaront part 2】Phase 2 trial was successful. / Clinical Trial Data

Introduction In Part2, I will write about the efficacy of Ulotaront, one of the most anticipated antipsychotic drugs of ...
Ulotaront

【Ulotaront part 1】Promising TAAR1 agonist

Introduction I have written several times that I am most excited about muscarinic agonists such as KarXT, Emraclidine, a...
Important Articles

Positive and Negative Syndrome Scale(PANSS, Scale used to measure efficacy)

Introduction What is PANSS? PANSS (Positive and Negative Syndrome Scale) is a scale used to measure the severity of schi...
Important Articles

About this blog

In this blog, I will try to provide the world with the latest information on "psychotropic drugs under development" (ant...
Muscarinic Agonists

【Emraclidine】Efficacy Compared to Current Drugs in Phase1b

Introduction Cerevel's Emraclidine(CVL-231) is the same type of drug as Neurocrine's NBI-1117568 and Karuna's KarXT. The...
Muscarinic Agonists

EMERGENT-2【KarXT】Efficacy Compared to Current Drugs in Phase3

Introduction I have something to say about the data from KarXT's Phase 3 trial, and I think the results of KarXT's Phase...